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UNDERGRADUATE COURSES
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| BIM 1 |
Introduction to Biomedical Engineering |
Units: 1 |
| Lecture: 1 hour. No prerequisites. The primary fields of specialization in biomedical engineering are introduced. Fields include the following: (1) sensors, instrumentation, and signal processing; (2) orthopedic biomechanics; (3) whole body biomechanics; (4) imaging, and (5) biofluids and transport (6) cell and molecular engineering. |
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| BIM 20 |
Fundamentals of Bioengineering |
Units: 4 |
Lecture: 4 hours. Prerequisite: Physics 9B; Mathematics 21D. Basic principles of mass, energy and momentum conservation equations applied to solve problems in the biological and medical sciences
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| BIM 102 |
Quantitative Cell Biology |
Units: 4 |
Lecture/discussion: 4 hours. Prerequisite(s): Biological Sciences 2A, Physics 9B, Mathematics 22B, Chemistry 8B. Use of engineering principles to understand fundamental cell biology. Emphasis on physical concepts underlying cellular processes including protein trafficking, cell motility, cell division and cell adhesion. Current topics including cell biology of cancer and stem cells will be discussed.
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| BIM 105 |
Probability and Statistics for Biomedical Engineers |
Units: 4 |
Lecture/discussion: 4 hours. Prerequisite: Mathematics 21D. Concepts of probability, random variables and processes, and statistical analysis with applications to engineering problems in biomedical sciences. Contents include discrete and continuous random variables, probability distributions and models, hypothesis testing, statistical inference and stochastic processes. Emphasis on BME applications.
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| BIM 106 |
Biotransport Phenomena |
Units: 4 |
| Lecture: 4 hours. Prerequisite: Neurobiology, Physiology, and Behavior 101 or equivalent, Physics 9B, Mathematics 22B. Principles of heat and mass transfer with applications to biomedical systems; emphasis on mass transfer across cell membranes and the design and analysis of artificial human organs, and basic fluid transport. |
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| BIM 107 |
Mathematical Methods for Biological Systems |
Units: 4 |
| Lecture - 3 hours; discussion - 1 hour. Prerequisite: Mathematics 22A and 22B. Essential mathematical and numerical techniques for engineering problems in medicine and biology. Contents include matrix algebra, linear transforms, ordinary and partial differential equations, probability and stochastic processes, and an introduction to Monte Carlo and molecular dynamics simulations. |
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| BIM 108 |
Biomedical Signals and Control |
Units: 4 |
| Lecture: 2 hours, discussion: 2 hours. Prerequisites: MAT 22A, B; ENG 100 (can be taken concurrently). Systems and control theory are applied to bioengineering problems. Topics include modeling, linearization, transfer functions, Laplace and Fourier transforms, closed-loop systems, design and simulation of controllers dynamic behavior and control of first and second order processes, stability, bode design, and features of biological control systems. A simulation term project using MATLAB and an oral presentation are required. |
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| BIM 109 |
Biomaterials |
Units: 4 |
| Lecture: 3 hours; discussion: 1 hour. Prerequisite: course 106. Mechanical and chemical properties of metallic, ceramic, and polymeric implant materials. Properties of bones, joints, and blood vessels. Cellular response to implants, including inflammation, blood coagulation, and wound and fracture healing. Biocompatibility of orthopaedic and cardiovascular materials. |
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| BIM 110 A, B |
Capstone Biomedical Engineering Design |
Units: 2 - 2 |
| Laboratory: 3 hours; lecture/discussion: 1 hour. Prerequisite: courses 107, 108, 109. Application of bioengineering theory and experimental analysis culminating in the design of a unique solution to a problem. The design may be geared towards current applications in applied biomechanics, biotechnology or medical technology. (Deferred grading only, pending completion of sequence.) |
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| BIM 111 |
Biomedical Instrumentation Laboratory |
Units: 4 |
| Lecture: 1 hour, lab: 4 hours. Prerequisites: BIS 1A; BIM 107; STA 120, 131A, or 130A; ENG 100. Basic biomedical signals and sensors are presented. Other topics include analog and digital records using electronic, hydrodynamic, and optical sensors, and measurements made at cellular, tissue and whole organism level. Experiments include genomics technology, nerve action, electrocardiography, mechanics of muscle, membranes, and noninvasive diagnostics in humans. Analysis will stress statistical principles and possible errors in experimental design. |
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| BIM 116 |
Physiology for Biomedical Engineers |
Units: 5 |
Lecture—2 hours; problem solving—3 hours; Writing. Prerequisite: Biological Sciences 2A, Mathematics 22B, Physics 9C. Basic human physiology for the nervous, cardiovascular, respiratory, gastrointestinal, renal, and endocrine systems. Emphasis on small group design projects and presentations in interdisciplinary topics relating biomedical engineering to medical diagnostic and therapeutic applications. |
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| BIM 117 |
Analysis of Molecular and Cellular Networks |
Units: 4 |
| Lecture: 3 hours; discussion: 1 hour. Prerequisite: Biological Sciences 1A and Mathematics 22B. Network themes in biology, emphasizing metabolic, genetic, and developmental networks. Mathematical and computational methods for analysis of such networks. Elucidation of design principles in natural networks. Engineering and ethical issues in the design of synthetic networks. |
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| BIM 118 |
Microelectromechanical Systems |
Units: 4 |
| Lecture-3 hours; Lab-2 hours. Prerequisite(s): Engineering 100, Engineering 35, Engineering 103 or Course 106, Chemistry 2A; recommend Engineering 104. Theory and practice of MEMS, including fundamentals of microfabrication techniques, microscale sensing and actuating principles, and microsystem designs and implementations. Demonstration laboratory sections, integrated with lectures, will be conducted weekly inside the North California Nanofabrication Center. |
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| BIM 126 |
Tissue Mechanics |
Units: 3 |
| Lecture--2 hours; laboratory/discussion--3 hours. Prerequisite: Exercise Science 103 and/or Engineering 45 and/or consent of instructor. Structural and mechanical properties of biological tissues, including bone, cartilage, ligaments, tendons, nerves, and skeletal muscle. |
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| BIM 140 |
Protein Engineering |
Units: 4 |
| Lecture: 3 hours, discussion: 1 hour. Prerequisites: BIS 1A, CHE 8B. Protein structure and function are described, together with BME tools and strategies. Topics include modern methods for designing, producing, and characterizing novel proteins and peptides, design strategies, computer modeling, heterologous expression, in vitro mutagenesis, protein crystallography, spectroscopic and calorimetric methods for characterization, and other techniques. |
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| BIM 141 |
Cell and Tissue Mechanics |
Units: 4 |
| Lecture: 3 hours, discussion: 1 hour. Prerequisites: Physics 9C; ENG 35; NPB 101. Mechanical properties that govern blood flow in the microcirculation and cell adhesion and motility are evaluated. Topics include constitutive equations of vasculature, tissue, and blood, blood rheology and viscoelasticity, biophysical aspects of cell migration, mitosis, apoptosis, and differentiation, red and white blood cell mechanics, remodeling of blood vessels in disease and engineering of blood vessels and cells. The design of functional tissue units is presented with clinical applications. |
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| BIM 142 |
Biomedical Imaging: Basic Principles and Practice |
Units: 4 |
| Lecture: 3 hours; term paper. Prerequisite: Course 108 (may be taken concurrently), Physics 9D and Mathematics 22B. Basic physics, engineering principles, and applications of biomedical imaging techniques including x-ray imaging, computed tomography, magnetic resonance imaging, ultrasound and nuclear imaging. |
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| BIM 151 |
Mechanics of DNA |
Units: 3 |
| Lecture—3 hours. Prerequisite: Biological Sciences 1A and Mathematics 22B. Structural, mechanical and dynamic properties of DNA. Topics include DNA structures and their mechanical properties, in vivo topological constraints on DNA, mechanical and thermodynamic equilibria, DNA dynamics, and their roles in normal and pathological biological processes. Offered in alternate years. |
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| BIM 161 A |
Biomolecular Engineering |
Units: 4 |
| Lecture--3 hours; discussion--1 hour. Prerequisite: Biological Sciences 1A, Chemistry 8B; upper division standing. Introduction to the basic concepts and techniques of biomolecular engineering such as recombinant DNA technology, protein engineering, and molecular diagnostics. |
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| BIM 161 L |
Biomolecular Engineering Laboratory |
Units: 2 |
| Laboratory/discussion--6 hours. Prerequisite: course 161A; upper division Biomedical Engineering major. Introduction to the basic techniques in biomolecular engineering. Laboratory and discussion sessions will cover basic techniques in DNA cloning, bacterial cell culture, protein expression, and data analysis. GE Credit: SciEng. |
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| BIM 161 S |
Biomolecular Engineering: Brief Course |
Unit: 1 |
Lecture - 1 hour. Prerequisite: Biological Sciences 1A; Chemistry 8B; course 161L concurrently. Basic concepts and techniques in biomolecular analysis, recombinant DNA technology, and protein purification
and analysis. Not open for credit to students who have completed Biomedical Engineering 161A. Summer Session only.
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| BIM 162 |
Quantitative Concepts in Biomolecular Engineering |
Units: 4 |
Lecture - 4 hours. Prerequisite: Mathematics 22B and Physics 9D. Introduction to fundamental physical mechanisms governing structure and function of biomacromolecules. Emphasis on a quantitative understanding of the nano- to microscale biomechanics of interactions between and within individual molecules, as well as of their assemblies, in particular membranes. Offered in alternate years.
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| BIM 173 |
Cell and Tissue Engineering |
Units: 4 |
| Lecture/discussion: 4 hours. Prerequisite(s): BIM 106 and BIM 109. Engineering principles to direct cell and tissue behavior and formation. Cell sourcing, controlled delivery of macromolecules, transport within and around biomaterials, bioreactor design, tissue design criteria and outcomes assessment. |
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| BIM 189 |
Topics in Biomedical Engineering |
Units: 1 - 5 |
| Prerequisite: consent of instructor. Topics in Biomedical Engineering. (A) Cellular and Molecular Engineering (B) Biomedical Imaging (C) Biomedical Engineering. May be repeated if topic differs. Not offered every year. |
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| BIM 190 A |
Upper Division Seminar in Biomedical Engineering |
Units: 1 |
| Seminar--1 hour. Prerequisite: upper division standing. In depth examination of research topics in a small group setting. Question and answer session with faculty members. May be repeated for credit. (P/NP grading only.) |
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| BIM 199 |
Special Study for Advanced Undergraduates |
Units: 1 - 5 |
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