Our group develops and applies optical techniques for diagnostics, surgical guidance, and basic investigations of physiology and pathophysiology. Towards these ends we are pursuing a wide range of collaborations (This page is under construction and may not be up to date).
We are developing quantitative imaging methods to assess microvascular and immunological changes in skin. While the primary target application is the assessment of reconstructive surgery, such techniques could impact the monitoring of other conditions such as diabetes, psoriasis, vascular anomalies, skin cancer, and graft-versus host disease.
Collaborators: Sava Sakadzic, Christene Huang, Mihail Climov, Curt Cetrulo
Retina / Glaucoma
We are identifying and validating imaging biomarkers for the detection of retinal diseases and glaucoma. The focus is on identifying functional, rather than structural disease markers.
Collaborators: Teresa Chen, Jeff Goldberg, Andy Huberman, Alf Dubra
Stroke / Spreading Depression/ Cerebrovascular Pathophysiology
We are using longitudinal imaging techniques to characterize the spatiotemporal evolution of stroke, both during the acute phase and during the recovery phase, when the brain initiates endogenous attempts at repair. Both hemodynamic and cellular changes and their complex interplay are being investigated.
Collaborators: Cenk Ayata, Eng Lo, Emiri Mandeville, Katharina Eikermann-Haerter, Frederic Lesage, Dmitriy Atochin, Paul Huang
We are using high-resolution optical imaging techniques to investigate neurovascular coupling during functional activation. Using a wide array of imaging and electrophysiology methods, we are asking questions such as: In which layer does the neurovascular response originate? Is neurovascular coupling cortical-layer specific?
Collaborators: Anna Devor, Maria Angela Franceschini
We are investigating clearing, imaging, and tractography techniques to quantify myocardial microstructure in health and disease. Applications of these 3D histology techniques for brain imaging are also being investigated.
Collaborators: David Sosnovik, Craig Goergen
Through accurate statistical models of imaging data, we are attempting to identify optimal estimation methods for extraction of physiologically relevant parameters (such as blood velocity).
Collaborators: Aaron Chan, Edmund Lam
Technology development: Our group is also developing optical technologies for deeper imaging and novel contrast mechanisms for describing biological tissues