Recent Publications

Tsourkas, P. K., Liu, W., Das, S., Pierce, S. K., and Raychaudhuri, S.* Discrimination of membrane antigen affinity by B cells requires dominance of kinetic proofreading over serial triggering (accepted for publication in Cellular and Molecular Immunology)

Skommer, J., Das S., Nair A., Brittain T, Raychaudhuri S.^* Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells. Apoptosis 2011, 16:619-26. 

Reddy, A. S., Tsourkas P., and Raychaudhuri S.* Monte Carlo study of B-cell receptor clustering mediated by antigen cross-linking and biased transport. Cellular and Molecular Immunology 2011 8:255-64.

Tsourkas, P. K., and Raychaudhuri, S.^* Monte Carlo investigation of diffusion of receptors and ligands that bind across opposing surfaces. Annals of Biomedical Engineering 2011, 39:427-442.

Raychaudhuri, S.^* Minimal model of a signaling network elucidates cell-to-cell stochastic variability in apoptosis. PLoS One 2010, 5:e11930.

Skommer, J., Brittain, T., Raychaudhuri, S.^* Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. Apoptosis 2010, 15:1223-1233.

Tsourkas, P. K., and Raychaudhuri, S.^* Modeling of B cell synapse formation by Monte Carlo simulation shows that directed transport of receptors is a potential formation mechanism. Cellular and Molecular Bioengineering 2010, 3:256-268. 

Raychaudhuri S.*, Skommer J., Henty K., Birch N., and Brittain T. Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Apoptosis 2010, 15:401-11.

Reddy A. S., Chilukuri S., and Raychaudhuri S.* Network of receptors characterize B cell receptor micro- and macro- clustering in a Monte Carlo model. Journal of Physical Chemistry B 2010, 114:487-94.

Tsourkas, P. K., Longo M., and Raychaudhuri, S.* Monte Carlo study of single molecule diffusion can elucidate the mechanism of B cell synapse formation. Biophysical Journal 2008, 95:1118-1125.

Raychaudhuri, S.*, Willgohs, E., Nguyen, T-N., Khan, E. M., and Goldkorn, T. Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis. Biophysical Journal 2008, 95:3559-62.

Tsourkas, P. K., Baumgarth, N., Simon, S. I., and Raychaudhuri, S.* Mechanisms of B Cell Synapse Formation Predicted by Monte Carlo Simulation. Biophysical Journal 2007, 92: 4196-4208.

Other Publications

Sarantos, M. R., Raychaudhuri, S., Lum, A. F., Staunton, D. E., and Simon, S. I. Leukocyte Function-associated Antigen 1-mediated Adhesion Stability is Dynamically Regulated through Affinity and Valency during Bond Formation with Intercellular Adhesion Molecule-1. Journal of Biological Chemistry 2005, 280:28290-28298.

Witt, C., Raychaudhuri, S., Chakraborty, and A. K., Robey. E. Directed Migration of Positively Selected Thymocytes Visualized in Real Time. PloS Biology 2005, 3: 1062–1069.

Lee, K-H., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T. N., Burack, W. R., Wu, H., Wang, J., Kanagawa, O., Markiewicz, M., Allen, P. M., Dustin, M. L., Chakraborty, A. K., Shaw, A. S., The Immunological Synapse Balances T Cell Receptor Signaling and Degradation. Science 2003, 302:1218-1222.

Raychaudhuri, S., Chakraborty, A. K., and Kardar, M., An Effective Membrane Model of the Immunological Synapse. Physical Review Letters 2003, 91: 208101.

Hori, Y., Raychaudhuri, S., and Chakraborty, A. K., Analysis of Pattern Formation and Phase Separation in the Immunological Synapse. Journal of Chemical Physics 2002, 117: 9491-9501.

Raychaudhuri, S., Shapir, Y., and Mukamel, S., Disorder and Funneling Effects on Exciton Migration in Treelike Dendrimers. Physical Review E 2002, 65:021803

Raychaudhuri, S. and Shapir Y., Scaling behavior of randomly alternating surface growth processes. Journal of Physics A 2002, 35:10705–10720.

Raychaudhuri, S., Shapir, Y., and Jorne, J., Roughness scaling of cyclical surface growth. Physical Review E 2001, 64:051604.

Raychaudhuri, S., Cranston, M., Przybyla, C., and Shapir, Y. Maximal height scaling of kinetically growing surfaces. Physical Review Letters 2001, 87:136101.

Raychaudhuri, S., Shapir, Y., Chernyak, V., and Mukamel, S. Excitonic funneling in extended dendrimers with nonlinear and random potentials.  Physical Review Letters 2000, 87:282-285.

Shapir, Y., Raychaudhuri, S., Foster, D. G., Jorne, J. Scaling behavior of cyclical surface growth. Physical Review Letters 2000, 84: 3029-3032.

Invited Review Articles

Skommer, J., Raychaudhuri, S., Wlodkowic, D. Timing is everything: stochastic origins of cell-to-cell variability in cancer cell death.  Frontiers in Bioscience 2011, 16:307-14.

Raychaudhuri, S.* How can we kill cancer cells: insights from the computational models of apoptosis. World Journal of Clinical Oncology 2010, 10:24-8.

Brittain, T., Skommer, J., Henty, K., Birch, N., and Raychaudhuri, S. A role for human neuroglobin in Apoptosis. IUBMB Life 2010, 62:878-85.

Brittain, T., Skommer, J., Raychaudhuri, S., and Birch, N. An antiapoptotic neuroprotective role for neuroglobin. International Journal of Molecular Sciences 2010, 11:2306-2321.

Witt, C., Raychaudhuri, S., and Chakraborty, A. K. Movies, Measurement and Modeling: the Three M’s of Mechanistic Immunology. Journal of Experimental Medicine 2005, 201: 501-504.

Book Chapter

S. Raychaudhuri, P. K. Tsourkas and E. Willgohs. “Computational modeling of receptor-ligand binding and cellular signaling processes” in “Biophysics Fundamentals I”, Edited by T. Jue. (Humana, 2008).

Research funding

NIH R01: A novel computational model of B cell signaling and activation