AFFILIATION
Biomedical Engineering, Biophysics, Immunology, and Applied Mathematics
RESEARCH INTEREST
Biological processes, such as cell growth, death, immune response to foreign pathogens, are extremely complex phenomena, regulated by the interplay of a large number of components interacting across many length and time scales. At the cellular level, for instance, such biological processes are typically initiated by receptor-ligand binding at the cell surface, which triggers intracellular signaling, which in turn regulates gene transcription that ultimately decides the cellular response. Our laboratory investigates the role of individual molecular and cellular components that underlie complex behavior in biological systems.
We apply statistical mechanics and numerical simulations (e.g. Monte Carlo) in order to solve problems of biomedical relevance. Current projects in our lab focus on molecular mechanism of B cell immune synapse formation and associated signaling, apoptotic cell death signaling and diseases.
RESEARCH FACILITY
Beowulf computer cluster – dual processor dual core nodes.
RESEARCH PAPERS
P. K. Tsourkas, N. Baumgarth, S. I. Simon, and S. Raychaudhuri. Mechanisms of B cell synapse formation predicted by Monte Carlo Simulation. Biophysical Journal. 92:4096-4208 (2007).
MANUSCRIPTS SUBMITED
P. K. Tsourkas, M. L. Longo, and S. Raychaudhuri. Monte Carlo study of single molecule diffusion can elucidate the mechanism of B cell synapse formation. (In revision, 2008)
S. Raychaudhuri, E. Willgohs, and T-N. Nguyen. Large cell-to-cell stochastic fluctuation is predicted in a Monte Carlo study of apoptotic cell death signaling. (Submitted, 2008)
S. Raychaudhuri, and P. K. Tsourkas. A simplified model of receptor diffusion and clustering during immunological synapse formation. (Submitted, 2008)
S. Raychaudhuri. A minimal signaling network can capture stochastic signaling mechanism of apoptosis. (Submitted, 2008)
P. K. Tsourkas, and S. Raychaudhuri. Biased Diffusion of BCR-Ag Complexes is a potential mechanism of immunological synapse formation in B cells. (Submitted, 2008)
BOOK CHAPTER
S. Raychaudhuri, and P. K. Tsourkas. “Computational modeling of receptor-ligand binding and cellular signaling processes” in "Biophysics Fundamentals I", Edited by T. Jue. (In Press, 2008).
Complete list of publications is available at
Raychaudhuri Lab Website
MAJOR RESEARCH INTEREST
Computational and mathematical modeling of complex biological systems, biophysics of receptor-ligand binding mediated cellular signaling processes, B cell recognition of antigen and signaling, cell death (apoptosis) signaling and diseases, cell-to-cell stochastic fluctuations in cellular signaling and design principles of signaling networks.
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