Research Interest
Our laboratory has projects spanning all aspects of image-guided drug delivery. Major areas of interest include the fusion of images between ultrasound, PET, MRI and CT, the development of activatable drug delivery vehicles, and the development of molecularly-targeted drug delivery vehicles. Members of our laboratory bring expertise in many areas including biomedical engineering, physics, electrical engineering, chemical engineering, mechanical engineering, computer science, material science, chemistry, and biology.Current Projects
Image-Guided Drug Delivery in Cancer
Translational Cardiovascular Nanomedicine
Ultrasonic Assessment of Therapeutic Response
Real-time Prediction and Validation of Ultrasonic Hyperthermia Profiles
Molecular Imaging in Cancer
Ultrasonic and Radiofrequency Electromagnetic Heating for Local Drug Delivery
Members of Dr. Ferrara’s Lab
Publicatons
2011
Jai Woong Seo, Shengping Qin, Lisa M. Mahakian, Katherine D. Watson, Azadeh Kheirolomoom, Katherine W. Ferrara. Positron emission tomography imaging of the stability of Cu-64 labeled dipalmitoyl and distearoyl lipids in liposomes. Journal of Controlled Release. In Press.
Christopher R. Anderson, Xiaowen Hu, Jose Tlaxca, Anne-Emilie Decleves, Robert Houghtaling, Kumar Sharma, Michael Lawrence, Katherine Ferrara, Joshua J. Rychak. Ultrasound Molecular Imaging of Tumor Angiogenesis with an Integrin Targeted Microbubble Contrast Agent. Investigative Radiology. April 2011.
Hu-Lowe DD, Chen E, Zhang L, Watson KD, Mancuso P, Lappin P, Wickman G, Chen JH, Wang J, Jiang X, Amundson K, Simon R, Erbersdobler A, Bergqvist S, Feng Z, Swanson TA, Simmons BH, Lippincott J, Casperson GF, Levin WJ, Gallo Stampino C, Shalinsky DR, Ferrara KW, Fiedler W, Bertolini F. Targeting Activin Receptor-Like Kinase 1 (ALK1) Inhibits Angiogenesis and Tumorigenesis Through a Mechanism of Action Complementary to Anti-VEGF Therapies. Cancer Res. 2011 Jan 6. PMID: 21212415
2010
Lai CY, Kruse DE, Caskey CF, Stephens DN, Sutcliffe P, Ferrara KW. Noninvasive Thermometry Assisted by a Dual-Function Ultrasound Transducer for Mild Hyperthermia. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 57, no. 12, December 2010
Kheirolomoom A, Mahakian LM, Lai CY, Lindfors HA, Seo JW, Paoli EE, Watson KD, Haynam EM, Ingham ES, Xing L, Cheng RH, Borowsky AD, Cardiff RD, Ferrara KW. Copper-Doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity. Mol Pharm. 2010 Dec 6;7(6):1948-58.PMID: 20925429
Rygh CB, Qin S, Seo JW, Mahakian LM, Zhang H, Adamson RH, Chen JQ, Borowsky AD, Cardiff RD, Reed RK, Curry FR, Ferrara KW. Longitudinal investigation of permeability and distribution of macromolecules in mouse malignant transformation using PET. Clin Cancer Res. 2010 Nov 24. PMID: 21106723
Seo JW, Mahakian LM, Kheirolomoom A, Zhang H, Meares CF, Ferdani R, Anderson CJ, Ferrara KW. Liposomal Cu-64 Labeling Method Using Bifunctional Chelators: Poly(ethylene glycol) Spacer and Chelator Effects. Bioconjug Chem. 2010 Jun 22. PMID: 20568726
Paoli EE, Kruse DE, Seo JW, Zhang H, Kheirolomoom A, Watson KD, Chiu P, Stahlberg H, Ferrara KW. An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation. J Control Release. 2010 Apr 2;143(1):13-22. PMID: 20006659
Qin S, Seo JW, Zhang H, Qi J, Curry FR, Ferrara KW. An imaging-driven model for liposomal stability and circulation. Mol Pharm. 2010 Feb 1;7(1):12-21.PMID: 19621944
Kheirolomoom A, Kruse DE, Qin S, Watson KE, Lai CY, Young LJ, Cardiff RD, Ferrara KW. Enhanced in vivo bioluminescence imaging using liposomal luciferin delivery system. J Control Release. 2010 Jan 25;141(2):128-36. Epub 2009 Sep 11.PMID: 19748536
Kruse DE, Lai CY, Stephens DN, Sutcliffe P, Paoli EE, Barnes SH, Ferrara KW. Spatial and temporal-controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors. IEEE Trans Biomed Eng. 2010 Jan;57(1):155-66.PMID: 20064754
Hu X, Zheng H, Kruse DE, Sutcliffe P, Stephens DN, Ferrara KW. A sensitive TLRH targeted imaging technique for ultrasonic molecular imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2010;57(2):305-16.PMID: 20178897 |
