2011

L. Marcu, “Fluorescence Lifetime Techniques in Multimodal Tissue Diagnostic Platform,” in Bio-Optics: Design and Application, OSA Technical Digest (CD) (Optical Society of America, 2011), paper BMB3. (Link)

Y. Sun, J. Meier, N. Hatami, J. Phipps, R. Schrot, B. Poirier, G. Farwell, D. Elson, and L. Marcu, “Fluorescence Lifetime Imaging Microscopy (FLIM) for Intraoperative Tumor Delineation: A Study in Patients,” in Bio-Optics: Design and Application, OSA Technical Digest (CD) (Optical Society of America, 2011), paper BWC6.

J. Bec, H. Xie, D.R. Yankelevich, F. Zhou, Y. Sun, N. Ghata, R.C. Aldredge, and L. Marcu, “Design, construction, and validation of a multimodal intravascular diagnostic catheter combining IVUS and fluorescence lifetime spectroscopy detection channels,” oral presentation, SPIE Photonics West, Jan. 22-27, 2011, San Francisco, CA.

Y. Sun, J. Phipps, M. Lam, H. Xie, M.C. Fishbein, J.M. Cannata, K. Shung, and L. Marcu, “Characterization of atherosclerotic plaques using combined time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy,” oral presentation, SPIE Photonics West, Jan. 22-27, 2011, San Francisco, CA.

H. Xie, J. Bec, Y. Sun, and L. Marcu, “Development of an intravascular diagnostic system integrating an IVUS-guided rotational fiber optics catheter for time-resolved fluorescence spectroscopy,” oral presentation, SPIE Photonics West, Jan. 22-27, 2011, San Francisco, CA.

2010

J. Phipps, N. Hatami, J. Jo, M.C. Fishbein, T. Papaioannou, Q. Fang, J. Baker, and L. Marcu, “Time resolved spectroscopy differentiates metalloproteinase levels in atherosclerotic plaques,” oral presentation, Biomedical Engineering Society Fall Meeting, Oct. 6-9, 2010, Austin, TX.

Y. Sun, Y.H. Sun, D.S. Elson, H. Xie, M. Lam, J. Phipps, S. Tinling, G. Farwell, J.M. Cannata, K. Shung, and L. Marcu, “Development of Multimodal Tissue Diagnostic System,” poster session, Biomedical Engineering Society Fall Meeting, Oct. 6-9, 2010, Austin, TX.

H. Xie, Y. Sun, and L. Marcu, “Time-resolved fluorescence spectroscopy for intraoperative diagnosis of oral cancer,” poster presentation, Biomedical Engineering Society Fall Meeting, Oct. 6-9, 2010, Austin, TX.

J. Phipps, Y.H. Sun, M.C. Fishbein, and L. Marcu, “Endoscopic Fluorescence Lifetime Imaging and an Automated Classification Algorithm for the Characterization of Human Atherosclerotic Plaques,” oral presentation, Optics within Life Sciences, Sept. 28-30, 2010, Quebec City, Quebec, Canada.

F. Knorr, Y.H. Sun, D. Yankelevich, S. Wachsmann-Hogiu, and L. Marcu, “Approach towards label-free, two-photon excited fluorescence endoscopy,” oral presentation, UC Systemwide Bioengineering Symposium, June 17-19, 2010, Davis, CA.

M. Lam, Y. Sun, Y.H. Sun, D.N. Stephens, H. Xie, J.M. Cannata, G. Farwell, and L. Marcu, “Synthetic aperture focusing technique for improved image quality of ultrasound backscatter microscopy and photoacoustic imaging,” oral presentation, UC Systemwide Bioengineering Symposium, June 17-19, 2010, Davis, CA.

J. Phipps, N. Hatami, J.A. Jo, M.C. Fishbein, D. Baker, T. Papaioannou, Q. Fang, and L. Marcu, “Fluorescence lifetime spectroscopy of human atherosclerotic plaque differentiates metalloproteinase expression levels,” oral presentation, UC Systemwide Bioengineering Symposium, June 17-19, 2010, Davis, CA.

Y. Sun, Y.H. Sun, D.N. Stephens, D.S. Elson, M. Lam, H. Xie, S. Tinling, G. Farwell, J.M. Cannata, K.K. Shung, and L. Marcu, “A novel multimodal tissue diagnostic system combining time-resolved fluorescence spectroscopy, ultrasound, and photoacoustic imaging,” poster presentation, UC Systemwide Bioengineering Symposium, June 17-19, 2010, Davis, CA.

H. Xie, Y. Sun, J. Meier, N. Hatami, G. Farwell, and L. Marcu, “Time-resolved fluorescence spectroscopy for intraoperative diagnosis of oral cancer,” oral presentation, UC Systemwide Bioengineering Symposium, June 17-19, 2010, Davis, CA.

Y. Sun, “Multimodal tissue diagnostic system combining time-resolved fluorescence spectroscopy, ultrasound and photoacoustic imaging,” invited talk, University of California Irvine Beckman Laser Institute Laser Microbeam and Medical Program seminar, June 10, 2010, Irvine, CA.

A. Lam, Y. Sun, B. Fite, K.S. Lam, and L. Marcu, “Europium as a Fluorescent Probe for Cancer Targeting,” poster presentation, UC Davis Undergraduate Research Conference, April 29-30, 2010, Davis, CA.

M. Lam, Y. Sun, and L. Marcu, “Development of Combined Time-Resolved Fluorescence Spectroscopy, Ultrasound Backscatter Microscopy and Photoacoustic Multimodality Imaging System,” poster presentation, UC Davis Undergraduate Research Conference, April 29-30, 2010, Davis, CA.

Y. Sun, Y. H. Sun, H. Xie, D. S. Elson, M. Lam, G. Farwell, J. M. Cannata, K. K. Shung, and L. Marcu, “Multimodal tissue diagnostic system combining time-resolved fluorescence spectroscopy ultrasound and photoacoustic imaging,” ASLMS, April 14-18, 2010, Phoenix, AZ.

Y. Sun, D. N. Stephens, J. Phipps, Y. H. Sun, H. Xie, M. Lam, D. S. Elson, G. Farwell, J. M. Cannata, K. K. Shung, and L. Marcu, “Multimodal tissue diagnostic system combining ultrasonic backscatter microscopy and time-resolved fluorescence spectroscopy for characterization of atherosclerotic plaques and tumors,” 10th Annual Ultrasonic Transducer Engineering Conference, April 14-16, 2010, Los Angeles, CA.

B. Z. Fite, M. Decaris, Y.H. Sun, Y. Sun, C. K. Ho, K. Leach, L. Marcu, “Noninvasive system for the evaluation of bioengineered tissue constructs combining time-resolved fluorescence and ultrasound imaging,” 7566-4, SPIE Photonics West  BIOS, Jan. 23-28 2010, San Francisco, CA.

J. Phipps, Y.H. Sun, R. Saroufeem, N. Hatami, and L. Marcu, “Endoscopic FLIM images of carotid plaque: an automated classification method,” oral presentation, SPIE BiOS Photonics West, Jan. 23-28 2010, San Francisco, CA.

Y. Sun, Y.H. Sun, D. N. Stephens, H. Xie, M. Lam, J. M. Cannata, G. Farwell, K. Shung, L. Marcu, “Development of a multimodal tissue diagnostic system combining time-resolved fluorescence spectroscopy, high-resolution ultrasound, and photoacoustic imaging,” 7555-1,  SPIE Photonics West  BIOS, Jan. 23-28 2010, San Francisco, CA.

Y.H. Sun, Y. Sun, D. Stephens, H. Xie, J. Phipps, H, D. S. Elson, and L. Marcu, “High-speed time and wavelength-resolved fluorescence measurement for dynamic spectroscopy and imaging,” oral presentation, SPIE Photonics West  BIOS, Jan. 23-28 2010, San Francisco, CA.

H. Xie, D. N. Stephens, Y. Sun, Y.H. Sun, L. Marcu, “A steerable IVUS guided multimodal catheter for in vivo time-resolved fluorescence spectroscopy,” 7548D-105, SPIE Photonics West  BIOS, Jan. 23-28 2010, San Francisco, CA.

2009

J.D. Meier, Y. Sun, Y.H. Sun, J. Phipps, N. Hatami, L. Marcu, and D. G. Farwell, “Fluorescence spectroscopy as a diagnostic tool in HNSCC,” Podium presentation at the American Academy of Otolaryngology – Head and Neck Surgery Foundation Annual Meeting and Oto Expo, October 4-7, 2009, San Diego, CA.

Y.H. Sun, J. Meier, N. Hatami, J. Phipps, D. S. Elson, R. J. Schrot, D. G. Farwell, and L. Marcu, “Endoscopic Fluorescence Lifetime Imaging Applied to Intraoperative Cancer Diagnosis for Non-Invasive Optical Biopsy,” 15th Annual Cancer Research Symposium, poster presentation, Sept. 24 – 25, 2009, Sacramento, CA.

J. Phipps, Y.H. Sun, N. Hatami, R. Saroufeem, and L. Marcu, “Endoscopic FLIM images of human atherosclerosis: a pixel by pixel plaque vulnerability classification method,” oral presentation, Biomedical Engineering Society Fall Meeting, Pittsburg, PA.

Y.H. Sun, “Fluorescence imaging and spectroscopy for disease diagnosis,” UCD Global Research Experience in Advanced Technologies (GREAT) Program, Interdisciplinary Research Symposium, Invited talk, August 27, 2009, Davis, CA.

J. Phipps, Y.H. Sun, N. Hatami, R. Saroufeem, and L. Marcu, “Endoscopic fluorescence lifetime imaging for the characterization of atherosclerotic plaque,” poster presentation, ECI – Advances in Optics for Biotechnology, Medicine , and Surgery XI: Clinical Challenges and Research Solutions, poster presentation, June 28 – July 2, 2009,  Burlington, VT.

Y. Sun, Y.H. Sun, D. N. Stephens, H. Xie, J. Phipps, M. Lam, N. Hatami, J. M. Cannata, K. K. Shung, and L. Marcu, “Multimodal Tissue Diagnostic System Combining Time-resolved Fluorescence Spectroscopy, Ultrasound, and Photoacoustic Imaging,” Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery XI Clinical Challenges and Research Solutions, Poster presentation, June 28 – July 2, 2009, Burlington, VT.

Y.H Sun, J. Phipps, D. S. Elson, J. Meier, N. Hatami, F. S. Chuang, R. J. Schrot, D. G. Farwell, and L. Marcu, “Endoscopic Fluorescence Lifetime Imaging for Intraoperative Disease Diagnosis,” Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery XI Clinical Challenges and Research Solutions, Poster presentation, June 28 – July 2, 2009, Burlington, VT.

H. Xie, D. N. Stephens, Y. Sun, Y.H. Sun, J. Phipps, J. Southard, W. Ferrier, L. Talken, and L. Marcu, “A Steerable IVUS Guided Multi-Modal Catheter for In-Vivo Time-Resolved Fluorescence Spectroscopy,” Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery XI Clinical Challenges and Research Solutions, Poster presentation, June 28 – July 2, 2009, Burlington, VT.

Y.H. Sun, J. Phipps, D. S. Elson, J. Meier, N. Hatami, F. S. Chuang, R. J. Schrot, D. G. Farwell, and L. Marcu, “Fluorescence Lifetime Imaging Microscopy (FLIM) for Cancer Demarcation during Medical Surgery,” 10^th Annual UC Systemwide Bioengineering Symposium, Oral presentation, June 19 – 21, 2009, Merced, CA.

J. Phipps, Y.H. Sun, N. Hatami, R. Saroufeem, and L. Marcu, “Endoscopic fluorescence lifetime imaging for the characterization of atherosclerotic plaque,” oral presentation, UC Systemwide Bioengineering Symposium, Merced, CA.

J. Phipps, Y.H. Sun, R. Saroufeem, N. Hatami, R. Saroufeem, and L. Marcu, “Fluorescence lifetime imaging microscopy for the characterization of atherosclerotic plaque,” oral presentation, SPIE BiOS Photonics West, Jan. 24, 2009, San Jose, CA.

2008

J. Park, D. N. Stephens, Y. Sun, L. Marcu. Use of a multi-functional catheter for time-resolved fluorescence spectroscopy guided by IVUS. Oct. 2-4, 29, 2008, St. Louis, MO.

J. Phipps, Y. Sun, N. Hatami, R. Saroufeem, L.  Marcu, Fluorescence lifetime imaging microscopy (FLIM) for the detection of atherosclerotic plaques, Biomedical Engineering Society Annual Fall Meeting, Oct. 2-4, 29, 2008, St. Louis, MO.

Y. Sun, J. Park, Y. Sun, D. N. Stephens, J. M. Cannata, K. K. Shung, L. Marcu, Multimodal system combining lifetime fluorescence spectroscopy, ultrasound and photoacoustic imaging,  Oct. 2-4, 2008, St. Louis, MO.

Y.H. Sun, Y. Sun, J. Phipps, J. Park, D. S. Elson, L. Marcu. Real-Time Tissue Diagnosis with Simultaneous Time- and Wavelength-Resolved Fluorescence Spectroscopy, Oct. 2-4, 29, 2008, St. Louis, MO.

H. Stoy, J. Park, Y. H. Sun, S. Tinling, D. Enepekides, G.D. Farwell, and L. Marcu,  A non-invasive diagnostic technique using time-resolved laser-induced fluorescence spectroscopy in the hamster model, To be presented at the 7th International Conference on Head and Neck Cancer, July 19-23, 2008, San Francisco, CA.

Y.H. Sun, J. Phipps, D. S. Elson, F. S. Frank, and L. Marcu, “Fluorescence Lifetime Imaging Microscopy coupled to fiber optics-based endoscope for carcinoma diagnosis in hamster model,” International Congress on Biophotonics, Feb. 3-7, 2008, Sacramento, CA.

 

 

Y. Sun, J. Park, J. A. Jo, D. N. Stephens, L. Sun, J. M. Cannata, Q. Zhou, K. K. Shung, and L. Marcu, “Tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasound imaging for localization and characterization of atherosclerotic plaques,” oral presentation, SPIE Photonics West  BIOS, Jan. 19-24, 2008, San Jose, CA.

Y. Sun, K.C. Liao, Y. H. Sun, J. Park, and L. Marcu, “Novel tissue phantom for testing a dual-modality tissue diagnostic system: time-resolved fluorescence spectroscopy and high frequency ultrasound,” oral presentation, SPIE Photonics West BIOS, Jan. 19-24, 2008, San Jose, CA.

Y.H. Sun, D. S. Elson, J. Phipps, H. Stoy, S. Tinling, F. S. Chuang, D. G. Farwell, and L. Marcu, “Fiber-optics based fluorescence lifetime imaging microscopy (FLIM) for the diagnosis of carcinoma,” SPIE Photonics West  BIOS, Jan. 19-24, 2008, San Jose, CA.

Y.H. Sun, R. Liu, C. Hollars, D.S. Elson, J. A. Jo, J. Park and L. Marcu,  “Simultaneous time- and wavelength-resolved spectroscopy aiming to the real-time tissue diagnosis,” SPIE Photonics West BIOS, Jan. 19-24, 2008, San Jose, CA.

P. Butte, A. N. Mamelak, S. Bannykh, J. A. Jo, K. Black, and L. Marcu, Intra-operative delineation of primary brain tumors by time-resolved fluorescence spectroscopy, oral presentation, SPIE Photonics West BIOS, Jan. 19-24, 2008, San Jose, CA.

J. Park, Y. Sun, D. N. Stephens, T. Papaioannou, L. Marcu, “Time-resolved fluorescence spectroscopy with single-fiber catheter for intravascular study,” oral presentation, SPIE Photonics West BIOS, Jan. 19-24, 2008, San Jose, CA.

J. Phipps, J. A. Jo, M. C. Fishbein, T. Papaioannou, Q. Fang, and J. D. Baker, and L. Marcu, “Differentiation of matrix metalloproteinase expression levels by fluorescence lifetime spectroscopy: A study in human carotid atherosclerotic plaques,” oral presentation, SPIE Photonics West BIOS, Jan. 19-24, 2008, San Jose, CA.

Y. H. Sun, D.S. Elson, J. Phipps, H. Stoy, S. Tinling, F.S. Chuang, G.D. Farwell, and L. Marcu,  “Fiber-Optic based fluorescence lifetime imaging microscopy (FLIM) for the diagnosis of carcinoma,” SPIE Photonics West BIOS, Jan. 19-24, 2008, San Jose, CA.

2007

P. Butte, A. N. Mamelak, S. Bannykh, J. A. Jo, K. Black, and L. Marcu, “Intra-operative time-resolved fluorescence spectroscopy of human gliomas,” oral presentation, Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, CA.

J. A. Jo, C. Klein, and L. Marcu, “Optimal emission bands for time-resolved fluorescence spectroscopy detection of vulnerable plaques, oral presentation,” Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, P655, 2007.

R. Liu, Y. H. Sun, C. Hollars, D.S. Elson, J. A. Jo, J. Park and L. Marcu, “Apparatus for simultaneous time- and wavelength-resolved spectroscopy of tissue,” poster, Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, CA.

E. Livak-Dahl, Y.H. Sun, J. Yan, A. Revzin, and L. Marcu, “Microfabrication of beads and test patterns for fluorescence lifetime imaging phantoms,” poster presentation at Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles.

J. Park, Y. Sun, D. N. Stephens, T. Papaioannou, L. Marcu, “Time-resolved fluorescence spectroscopy for percutaneous investigation of atherosclerotic plaques,” oral presentation, Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, CA.

J. Phipps, J. Park, J. A. Jo, L. Marcu, “Graphical user interface for near real time analysis of atherosclerotic plaque composition,” oral presentation, Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, CA.

D. N. Stephens, M. Cochran, Y. Sun, P. A. Dayton, T. Papaioannou, and L. Marcu, “Arterial characterization with both optical and IVUS catheters,” oral presentation, Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, CA.

Y. Sun, K. C. Liao, Y. H. Sun, J. Park, and L. Marcu, “Tissue phantom for testing a dual-modality diagnostic system: optical spectroscopy and ultrasound,” poster, Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles,  CA.

Y. Sun, J. Park, J. A. Jo, D. N. Stephens, L. Sun, J. M. Cannata, K. K. Shung, and L. Marcu, “Development of a tissue diagnostic system combining fluorescence spectroscopy and ultrasound imaging ,” oral presentation, Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, CA.

Y.H. Sun, D. S. Elson, J. Phipps, F. S. Chuang, and L. Marcu, “Compact fluorescence lifetime imaging microscopy system with applications to tumor diagnosis in vivo,” Biomedical Engineering Society Annual Fall Meeting, Sept. 26-29, 2007, Los Angeles, CA.

Y.H. Sun, J. Park, J. Phipps, Y. Sun, D. S. Elson, F. Chuang, and L. Marcu, “Time resolved laser induced fluorescence spectroscopy and fluorescence imaging microscopy,” the Center for Biophotonics Science &Technology NSF Site Review, May 30, 2007, Sacramento, CA.

Y.H. Sun, J. Phipps, D. S. Elson, F. S. Frank, and L. Marcu, “Endoscopic Fluorescence Lifetime Imaging Microscopy,” NSF Center for Biophotonics Science and Technology Spring Science Workshop, April 4 -6, 2007, Sacramento, CA.