PUBLICATIONS

2009

Y. H. Sun, J. Phipps, D. S. Elson, H. Stoy, S., S. Tinling, J. Meier, B. Poirier, F. S. Chuang, D. G. Farwell, and L. Marcu, Fluorescence lifetime imaging microscopy: In vivo application to diagnosis of oral carcinoma, Optics Letters, Volume 34, Issue 13, pp. 2081-2083, 2009. (Link)  (PDF)

D.N. Stephens, J. Park, Y. Sun, T. Papaioannou, and L. Marcu, Intraluminal fluorescence spectroscopy catheter with ultrasound guidance, Journal of Biomedical Optics, 14, 030505 (2009), DOI:10.1117/1.3146813. (Link)  (PDF)

Y. Sun, J. Park, D.N. Stephens, J.A. Jo, L. Sun, J.M. Cannata, R. M.G. Saroufeem, K.K. Shung, and L. Marcu, Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy, Review of Scientific Instruments, 80, 065104 (2009), DOI:10.1063/1.3142478. (Link)  (PDF)

J. Yan, Y. Sun, H. Zhu, L. Marcu, A. Revzin, Enzyme-containing hydrogel micropatterns serving a dual purpose of cell sequestration and metabolite detection, Biosensors and Bioelectronics, Volume 24, Issue 8, 2604-10, 2009. (Link)  (PDF)

J. Lo, S.J. Chen, Q. Fang, T. Papaioannou, E.S. Kim, M. Gundersen, L. Marcu, Performance of a diaphragmed microlens for a packaged microspectrometer, Accepted in Sensors, February 2009. (Link) (PDF)

L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J-H Qiao, J. D. Baker, J. A. Freischlag, M. C. Fishbein, Detection of Rupture-Prone Atherosclerotic Plaques by Time-Resolved Laser Induced Fluorescence Spectroscopy, Atherosclerosis, 2009. (Link)  (PDF)

V. Saxena, L. Marcu and G. Karunasiri. A novel noninvasive all optical technique to monitor physiology of an exercising muscle. Physics in Medicine and Biology, 53(21):6211-25, 2008. (Link) (PDF)

Y. H. Sun, R. Liu, D. S. Elson, C. Hollars, J. A. Jo, J. Park, Y. Sun, and L. Marcu, Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis, Optics Letters, Vol. 33(6):630-632, 2008. (Link) (PDF)

K-C. Liao, T. Hogen-Esch, F. J. Richmond, L. Marcu, W. Clifton, G. E. Loeb, Percutaneous fiber-optic sensor for chronic glucose monitoring in vivo. Biosensors and Bioelectronics 23:1458–1465, 2008. (Link) (PDF)

J. Wang, W. H. Yong, Y. Sun, P. T. Vernier, H. P. Koeffler, M. A. Gundersen, L. Marcu. Receptor-targeted quantum dots: fluorescence probes for brain tumor diagnosis. Journal of Biomedical Optics 12(4):044021, 2007. (Link) (PDF)

J. F. Lo, Q. Fang, L. Marcu, E. S. Kim, Wafer-level packaging of three-dimensional MOEMS device with lens diaphragm, Micro Electro Mechanical Systems, 2007. MEMS. IEEE 20th International Conference on 21-25 Jan. 2007 Pages:715 – 718. (Link) (PDF)

D. S. Elson, J. A. Jo, L Marcu. Miniaturized side-viewing imaging probe for fluorescence lifetime imaging (FLIM): validation with fluorescence dyes, tissue structural proteins and tissue specimens. New Journal of Physics 9, 127, 2007. (Link) (PDF)

E. B. Garon, D. Sawcer, David, P. T. Vernier, T. Tang, Y. Sun, L. Marcu, M. A. Gundersen, H. P. Koeffler, In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies, International Journal of Cancer, 121: 675-82, 2007. (Link) (PDF)

E. B. Garon, L. Marcu, Q. Luongc, O. Tcherniantchouk, G. M. Crooks, H. P. Koeffler, Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells, Leukemia Research, 31, 643-651, 2007. (Link) (PDF)

J.A. Jo, L. Marcu, Q. Fang Q, T. Papaioannou, J.H. Qiao, M.C. Fishbein, B. Beseth, A.H. Dorafshar, T. Reil, D. Baker, J. A. Freischlag, New methods for time-resolved fluorescence spectroscopy data analysis based on the Laguerre expansion technique - Applications in tissue diagnosis, Methods of Information on Medicine 46(2): 206-211, 2007. (Link)

2006

J. A. Jo, Q. Fang, T. Papaioannou, J. Qiao, M. C.  Fishbein, B. Beseth, A. Dorafshar, T. Reil, D. Baker, J. Freischlag, K.K. Shung, L. Sun, L. Marcu. “Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging.” 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, New York City, New York. August 2006. pp:2663-2666. (Link) (PDF)

W. H. Yong, P. V. Butte, Brian K. Pikul, J. A. Jo, K. L. Black, MD, L. Marcu, Distinction of Brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy, Frontiers in Biosciences, 11:1255-63, 2006. (Link)

Y. Sun, Y.-S Liu, P. T. Vernier, C.-H. Liang, S. Y. Chong, L. Marcu, and M. A. Gundersen, "Photostability and pH sensitivity of CdSe/ZnSe/ZnS quantum dots in living cells,"Nanotechnology 17:4469-476, 2006. (Link) (PDF)

Y. Sun, P. T. Vernier, M. Behrend, J. Wang, M. A. Gundersen, L. Marcu. Fluorescence microscopy imaging of electroperturbation in mammalian cells. Journal of Biomedical Optics, Vol. 11(2): 024010-1 "024010-7, 2006. (Link) (PDF)

J. A. Jo, Q. Fang, T. Papaioannou, J. Qiao, M. C. Fishbein, A. Dorafshar, T. Reil, D. Baker, J. Freischlag, L. Marcu, "Laguerre Based Method for Analysis of Time-Resolved Fluorescence Data: Application to In-Vivo Characterization and Diagnosis of Atherosclerotic Lesions,"Journal of Biomedical Optics, Vol. 11(2):021004-1 "021004-13, 2006. (Link) (PDF)

L. Marcu, G.J. Tearney, K.W. Gregory, Cardiovascular photonics, Journal of Biomedical Optics 11 (2):021001, 2006. (Link) (PDF)

2005

P. T. Vernier, S. Yinghua, J. Wang, M.M. Thu, E. Garon, M. Valderrabano, L. Marcu, H.P. Koeffler, M. A. Gundersen; Nanoelectropulse Intracellular Perturbation and Electropermeabilization Technology: Phospholipid Translocation, Calcium Bursts, Chromatin Rearrangement, Cardiomyocyte Activation, and Tumor Cell Sensitivity; The 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, September 2005; pp: 5850 - 5853. (Link) (PDF)

J. A. Jo; Q. Fang, T. Papaioannou, J. H. Qiao, M.C. Fishbein, B. Beseth, A. H. Dorafshar, T. Reil, D. Baker, J. A. Freischlag, L. Marcu. Application of the Laguerre Deconvolution Method for Time-Resolved Fluorescence Spectroscopy to the Characterization of Atherosclerotic Plaques; The 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, September 2005; pp: 6559 - 6562. (Link) (PDF)

P. V. Butte, B. K. Pikul, A. Hever, W. H. Yong, K. L. Black, L. Marcu, "Diagnosis of meningioma by time resolved fluorescence spectroscopy, "Journal of Biomedical Optics. 10(6):064026-1 - 064026-9, 2005. (Link) (PDF)

J. A. Jo, Q. Fang, T. Papaioannou, L. Marcu, "Ultra-fast method for the analysis of fluorescence lifetime imaging microscopy based on the Laguerre expansion technique,"IEEE Journal of Selected Topics in Quantum Electronics and Biophotonics, 11(4):835-845, 2005. (Link) (PDF)

Y. Sun, P. T. Vernier, M. Behrend, L. Marcu, M. A. Gundersen, Electrode microchamber for non-invasive perturbation of mammalian cells with nanosecond pulsed electric fields, IEEE NanoBioscience, 4(4):277-283, 2005. (Link) (PDF)

T. K. Hsiai, M. Rouhinizadeh, R. E. Clempus; L. Marcu, B. Lassègue, J. Hwang, A. Sevanian. PhDOx-PAPC Induces Superoxide Production via NADPH Oxidase. Free Radical Biology and Medicine. 39:1512-1522, 2005. (Link)  (PDF)

L. Marcu, J. A. Jo, Q. Fang, and T. Papaioannou.  “Applications of Time-Resolved Fluorescence Spectroscopy to Atherosclerotic Cardiovascular Disease and Brain Tumors Diagnosis”, CLEO/QELS,  Baltimore, May 22-27, Vol. 1:CFJ3-J5. (Link)  (PDF)

L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, A. Dorafshar, T. Reil, J.H. Qiao, D. Baker, M. C. Fishbein, J. A. Freischlag. In-Vivo Detection of Macrophages in a Rabbit Atherosclerotic Model by Time-Resolved Laser-Induced Fluorescence Spectroscopy. Atherosclerosis, Vol. 181(2): 295-303, 2005. (Link)  (PDF)

O. V. Ivanova, L. Marcu, M. C. K. Khoo, Nonparametric recognition of fluorescent system for tissue characterization: Simultaneous deconvolution in wavelength and time dimensions. Annals of Biomedical Engineering. 33(4): 529-542, 2005. (Link) (PDF)

2004

Taroni P., Valentini G, and L. Marcu "Fluorescence spectroscopy and imaging" In Lasers and current optical techniques in biology, ESP Series Comprehensive Series in Photosciences, Vol. 4, Donat-P. Häder, Giulio Jori Series Eds. Vol. 4:259-330, 2004.

K. C. Liao, F. J. Richmond, T. Hogen-Esch, L. Marcu, G. E. Loeb “Sencil Project: Development of a Percutaneous Optical Biosensor.” The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California. September 2004. (Link) (PDF)

J. A. Jo, Q. Fang, T. Papaioannou, J. Qiao, M. C.  Fishbein, A. Dorafshar, T. Reil, D. Baker, J. Freischlag, L. Marcu. “Novel Methods of Time-Resolved Fluorescence Data Analysis for In-Vivo Tissue Characterization: Application to Atherosclerosis.” 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California. September 2004; Vol. 1: 1372-1375. (Link) (PDF)

J. A. Jo, Q. Fang, T. Papaioannou, L. Marcu. “Novel Ultra-Fast Deconvolution Method for Fluorescence Lifetime Imaging Microscopy Based on the Laguerre Expansion Technique.” 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, California. September 2004; Vol. 1: 1271-1274. (Link) (PDF)

L. Marcu. “Fluorescence spectroscopy and imaging: Part II”, In Lasers and current optical techniques in biology, ESP Series Comprehensive Series in Photosciences, Donat-P. Häder, Giulio Jori Series eds. Vol. 4:291-325.
P. T. Vernier, Y. Sun, L. Marcu, C. M. Craft, and M. A. Gundersen, "Nanosecond pulsed electric fields perturb membrane phospholipids in T lymphoblasts" FEBS Letters 572:103-108, 2004. (Link) (PDF)

L. Marcu, J. A. Jo, P. V. Butte, W.H. Yong, B. K. Pikul, K. L. Black, R. C. Thompson, Fluorescence lifetime spectroscopy of glioblastoma multiforme, Photochemistry and Photobiology, 80(1): 98-103, 2004. (Link) (PDF)

P. T. Vernier, Y. Sun, L. Marcu, C. M. Craft, and M. A. Gundersen. Nanoelectropulse-Induced Phosphatidylserine Translocation, Biophysical Journal, 86(6): 4040-4048, 2004. (Link) (PDF)

T. Papaioannou, N. Preyer, Q. Fang, M. Carnohan, R. Ross, A. Brightwell, G. Cottone, L. Jones, L. Marcu, "Effect of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm" Applied Optics, Vol. 43(14): 2846-2860, 2004. (Link) (PDF)

J. A. Jo, Q. Fang, T. Papaioannou, L. Marcu. "Fast model-free deconvolution of fluorescence decay for analysis of biological systems" Journal of Biomedical Optics, 9(4):743-752, 2004. (Link) (PDF)

P. Ashjian, A. Elbarbary, P. Zuk, D. A. DeUgarte, P. Benhaim, M. H. Hedrick, L. Marcu. "Non-invasive in-situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy" Tissue Engineering, 10(3/4):411-420, 2004. (Link) (PDF)

P. T. Vernier, M. Thu, L. Marcu, C. M. Craft, and M. A. Gundersen, "Nanosecond Electroperturbation-mammalian Cell Selectivity and Bacterial resistance" IEEE Transactions on Plasma Science, 32:1620-1625, 2004.  (Link) (PDF)

Q. Fang, T. Papaioannou, J. Jo, R. Vaitha, K. Shastry, and L. Marcu, "Time-domain laser-induced fluorescence apparatus for clinical diagnostics," Review of Scientific Instruments 75(1):151-162, 2004. (Link) (PDF)

2003

J. A. Jo, Q. Fang, T. Papaioannou, L. Marcu,  "Nonparametric Analysis Of Time-Resolved Fluorescence Data Based On The Laguerre Expansion Technique".  25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico. IEEE-EMBC Proc, pp:1015-1018. (Link) (PDF)

L. Marcu, W. S. Grundfest, M. C. Fishbein, "Time-resolved Laser-Induced Fluorescence Spectroscopy for Staging Atherosclerotic Lesions" In Fluorescence in Biomedicine. M.A. Mycek and B. Pogue Eds, Marcel Dekker, New York, pp: 397-430, 2003.

P. T. Vernier, Y. Sun, L. Marcu, S. Salemi, C. M. Craft, and M. A. Gundersen. "Intracellular Calcium Bursts Induced by Nanosecond Electric Pulses" Biochemical and Biophysical Research Communications, 310:286-295, 2003. (Link) (PDF)

P. T. Vernier, A. Li, L. Marcu, C. M. Craft, and M. A. Gundersen, "Ultrashort pulsed electric fields induce membrane phospholipid translocation and caspase activation: differential sensitivities of Jurkat T lymphoblasts and rat glioma C6 cells" IEEE Transactions on Dielectrics and Electrical Insulators, 10:795-809, 2003. (Link) (PDF)

M. Behrend, A. Kuthi, X. Gu, P. T. Vernier, L. Marcu, C. M. Craft, and M. A. Gundersen, "Pulse Generators for Pulsed Electric Field Exposure of Biological Cells and Tissues" IEEE Transactions on Dielectrics and Electrical Insulators, 10:820-825, 2003. (Link) (PDF)

2001

L. Marcu, M. Fishbein, J.M. Maarek, W.S. Grundfest, “Discrimination of Human Coronary Artery atherosclerotic Lipid-Rich lesions by time-resolved laser-induced fluorescence spectroscopy”, Atherosclerosis Thrombosis and Vascular Biology.  21(7):1244-1250. (Link) (PDF)

2000

J. M. Maarek, L. Marcu, M. Fishbein, W. S. Grundfest, "Time-resolved fluorescence of aortic wall: use for improved identification of atherosclerotic lesions."Lasers Surg Med. 27:241-254, 2000. (Link) (PDF)

J. M. Maarek, L. Marcu, W. J. Snyder, W. S. Grundfest, "Time-resolved fluorescence spectra of arterial fluorescent compounds reconstruction with Laguerre expansion technique."Photochem. Photobiol. 71:178-187, 2000. (Link) (PDF)

1999

L. Marcu, W. S. Grundfest, J. M. Maarek, "Photobleaching of arterial fluorescent compounds: characterization of elastin, collagen, and cholesterol time-resolved spectra during prolonged ultraviolet irradiation", Photochem Photobiol 69:713-721, 1999. (Link) (PDF)