PUBLICATIONS

2007

J. Wang, W. H. Yong, Y. Sun, P. T. Vernier, H. P. Koeffler, M. A. Gundersen, L. Marcu. Receptor-targeted quantum dots: fluorescence probes for brain tumor diagnosis. Journal of Biomedical Optics 12(4):044021, 2007.(PDF)

D. S. Elson, J. A. Jo, L Marcu.Miniaturized side-viewing imaging probe for fluorescence lifetime imaging (FLIM): validation with fluorescence dyes, tissue structural proteins and tissue specimens. New Journal of Physics 9, 127, 2007. (PDF)

E. B. Garon, D. Sawcer, David, P. T. Vernier, T. Tang, Y. Sun, L. Marcu, M. A. Gundersen, H. P. Koeffler, In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies, International Journal of Cancer, 121: 675"82, 2007.(PDF)

E. B. Garon, L. Marcu, Q. Luongc, O. Tcherniantchouk, G. M. Crooks, H. P. Koeffler, Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells, Leukemia Research, 31, 643-651, 2007.(PDF)

J.A. Jo, L. Marcu, Q. Fang Q, T. Papaioannou, J.H. Qiao, M.C. Fishbein, B. Beseth, A.H. Dorafshar, T. Reil, D. Baker, J. A. Freischlag, New methods for time-resolved fluorescence spectroscopy data analysis based on the Laguerre expansion technique - Applications in tissue diagnosis, Methods of Information on Medicine 46(2): 206-211, 2007.

2006

Y. Sun, Y.-S Liu, P. T. Vernier, C.-H. Liang, S. Y. Chong, L. Marcu, and M. A. Gundersen, "Photostability and pH sensitivity of CdSe/ZnSe/ZnS quantum dots in living cells,"Nanotechnology 17:4469"476, 2006.(PDF)

J. A. Jo, Q. Fang, T. Papaioannou, J. Qiao, M. C. Fishbein, A. Dorafshar, T. Reil, D. Baker, J. Freischlag, L. Marcu, "Laguerre Based Method for Analysis of Time-Resolved Fluorescence Data: Application to In-Vivo Characterization and Diagnosis of Atherosclerotic Lesions,"Journal of Biomedical Optics, Vol. 11(2):021004-1 "021004-13, 2006. (PDF)

L. Marcu, G.J. Tearney, K.W. Gregory, Cardiovascular photonics, Journal of Biomedical Optics 11 (2):021001, 2006(PDF)

Sun, P. T. Vernier, M. Behrend, J. Wang, M. A. Gundersen, L. Marcu. Fluorescence microscopy imaging of electroperturbation in mammalian cells. Journal of Biomedical Optics, Vol. 11(2): 024010-1 "024010-7, 2006. (PDF)

W. H. Yong, P. V. Butte, Brian K. Pikul, J. A. Jo, K. L. Black, MD, L. Marcu, Distinction of Brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy, Frontiers in Biosciences, 11:1255-63, 2006.(PDF)

2005

P. V. Butte, B. K. Pikul, A. Hever, W. H. Yong, K. L. Black, L. Marcu, "Diagnosis of meningioma by time resolved fluorescence spectroscopy, "Journal of Biomedical Optics. 10(6):064026-1 - 064026-9, 2005.(PDF)

J. A. Jo, Q. Fang, T. Papaioannou, L. Marcu, "Ultra-fast method for the analysis of fluorescence lifetime imaging microscopy based on the Laguerre expansion technique,"IEEE Journal of Selected Topics in Quantum Electronics and Biophotonics, 11(4):835-845, 2005. (PDF)

T. K. Hsiai, M. Rouhinizadeh, R. E. Clempus; L. Marcu, B. Lassègue, J. Hwang, A. Sevanian. PhDOx-PAPC Induces Superoxide Production via NADPH Oxidase. Free Radical Biology and Medicine. 39:1512-1522, 2005.

Y. Sun, P. T. Vernier, M. Behrend, L. Marcu, M. A. Gundersen, Electrode microchamber for non-invasive perturbation of mammalian cells with nanosecond pulsed electric fields, IEEE NanoBioscience, 4(4):277-283, 2005.(PDF)

L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, A. Dorafshar, T. Reil, J.H. Qiao, D. Baker, M. C. Fishbein, J. A. Freischlag. In-Vivo Detection of Macrophages in a Rabbit Atherosclerotic Model by Time-Resolved Laser-Induced Fluorescence Spectroscopy. Atherosclerosis, Vol. 181(2): 295-303, 2005.(PDF)

O. V. Ivanova, L. Marcu, M. C. K. Khoo, Nonparametric recognition of fluorescent system for tissue characterization: Simultaneous deconvolution in wavelength and time dimensions. Annals of Biomedical Engineering. 33(4): 529-542, 2005. (PDF)

2004

L. Marcu, J. A. Jo, P. V. Butte, W.H. Yong, B. K. Pikul, K. L. Black, R. C. Thompson, Fluorescence lifetime spectroscopy of glioblastoma multiforme, Photochemistry and Photobiology, 80(1): 98-103, 2004. (PDF)

T. Papaioannou, N. Preyer, Q. Fang, M. Carnohan, R. Ross, A. Brightwell, G. Cottone, L. Jones, L. Marcu, "Effect of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm" Applied Optics, Vol. 43(14): 2846-2860, 2004.

P. T. Vernier, Y. Sun, L. Marcu, C. M. Craft, and M. A. Gundersen. Nanoelectropulse-Induced Phosphatidylserine Translocation, Biophysical Journal, 86(6): 4040-4048, 2004.(PDF)

P. Ashjian, A. Elbarbary, P. Zuk, D. A. DeUgarte, P. Benhaim, M. H. Hedrick, L. Marcu. "Non-invasive in-situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy" Tissue Engineering, 10(3/4):411-420, 2004.(PDF)

Q. Fang, T. Papaioannou, J. Jo, R. Vaitha, K. Shastry, and L. Marcu, "Time-domain laser-induced fluorescence apparatus for clinical diagnostics,"Review of Scientific Instruments 75(1):151-162, 2004.(PDF)

P. T. Vernier, Y. Sun, L. Marcu, C. M. Craft, and M. A. Gundersen, "Nanosecond pulsed electric fields perturb membrane phospholipids in T lymphoblasts" FEBS Letters 572:103-108, 2004.(PDF)

Taroni P., Valentini G, and L. Marcu "Fluorescence spectroscopy and imaging" In Lasers and current optical techniques in biology, ESP Series Comprehensive Series in Photosciences, Vol. 4, Donat-P. Häder, Giulio Jori Series Eds. Vol. 4:259-330, 2004.

J. A. Jo, Q. Fang, T. Papaioannou, L. Marcu. "Fast model-free deconvolution of fluorescence decay for analysis of biological systems" Journal of Biomedical Optics, 9(4):743-752, 2004. (PDF)

P. T. Vernier, M. Thu, L. Marcu, C. M. Craft, and M. A. Gundersen, "Nanosecond Electroperturbation-mammalian Cell Selectivity and Bacterial spore resistance" IEEE Transactions on Plasma Science, 32:1620-1625, 2004. (PDF)

2003

P. T. Vernier, Y. Sun, L. Marcu, S. Salemi, C. M. Craft, and M. A. Gundersen. "Intracellular Calcium Bursts Induced by Nanosecond Electric Pulses" Biochemical and Biophysical Research Communications, 310:286-295, 2003.(PDF)

P. T. Vernier, A. Li, L. Marcu, C. M. Craft, and M. A. Gundersen, "Ultrashort pulsed electric fields induce membrane phospholipid translocation and caspase activation: differential sensitivities of Jurkat T lymphoblasts and rat glioma C6 cells" IEEE Transactions on Dielectrics and Electrical Insulators, 10:795-809, 2003.(PDF)

M. Behrend, A. Kuthi, X. Gu, P. T. Vernier, L. Marcu, C. M. Craft, and M. A. Gundersen, "Pulse Generators for Pulsed Electric Field Exposure of Biological Cells and Tissues" IEEE Transactions on Dielectrics and Electrical Insulators, 10:820-825, 2003.(PDF)

L. Marcu, W. S. Grundfest, M. C. Fishbein, "Time-resolved Laser-Induced Fluorescence Spectroscopy for Staging Atherosclerotic Lesions" In Fluorescence in Biomedicine. M.A. Mycek and B. Pogue Eds, Marcel Dekker, New York, pp: 397-430, 2003.

2001

L. Marcu, M. C. Fishbein, J. M. Maarek, W. S. Grundfest, "Discrimination of lipid-rich atherosclerotic lesions of human coronary artery by time-resolved laser-induced fluorescence spectroscopy" Atheroscler Thromb Vasc Biol. 21:1244-1250, 2001.(PDF)

2000

J. M. Maarek, L. Marcu, M. Fishbein, W. S. Grundfest, "Time-resolved fluorescence of aortic wall: use for improved identification of atherosclerotic lesions."Lasers Surg Med. 27:241-254, 2000 (PDF)

J. M. Maarek, L. Marcu, W. J. Snyder, W. S. Grundfest, "Time-resolved fluorescence spectra of arterial fluorescent compounds reconstruction with Laguerre expansion technique."Photochem. Photobiol. 71:178-187, 2000.(PDF)

1999

L. Marcu, W. S. Grundfest, J. M. Maarek, "Photobleaching of arterial fluorescent compounds: characterization of elastin, collagen, and cholesterol time-resolved spectra during prolonged ultraviolet irradiation", Photochem Photobiol 69:713-721, 1999.(PDF)