Publications
search of all papers from the Leach lab.
2012
Murphy KC, Leach JK. A reproducible, high throughput method for fabricating fibrin gels. BMC Res Notes. 2012 August;5:423. 
Decaris M, Binder BY, Soicher M, Bhat A, Leach JK. Cell-derived matrix coatings for polymeric scaffolds. Tissue Engineering Part A. 2012 Oct;18(19-20):2148-57.
Morales-Hernandez DG, Genetos DC, Murphy KC, Leach JK. Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. J. Funct. Biomater. 2012 May;3(2), 382-397. Link
He J, Decaris M, Leach JK. Bioceramic-mediated trophic factor secretion by mesenchymal stem cells enhances in vitro endothelial cell persistence and in vivo angiogenesis. Tissue Engineering Part A. 2012 Jul;18(13-14):1520-8.
Hoch AI, Binder BY, Genetos DC, Leach JK. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One. 2012 April;7(4):e35579.
Decaris ML, Mojadedi A, Bhat A, Leach JK. Transferable cell-secreted extracellular matrices enhance osteogenic differentiation. Acta
Biomaterialia. 2012 Feb;8(2):744-52.
2011
Bhat A, Boyadjiev SA, Senders CW, Leach JK. Differential growth factor adsorption to calvarial osteoblast-secreted extracellular matrices instructs osteoblastic behavior. PLoS One. 2011;6(10):e25990.
Man A, Davis HE, Ito A, Leach JK, Bannerman P. Neurite outgrowth in fibrin gels is regulated by substrate stiffness. Tissue Eng Part A. 2011 Dec;17(23-24):2931-42.
Davis HE, Case EM, Miller SL, Genetos DC, Leach JK. Osteogenic response to BMP-2 of hMSCs grown on apatite-coated scaffolds. Biotechnol Bioeng. 2011 Nov;108(11):2727-35.
Fite BZ, Decaris M, Sun Y, Sun Y, Lam A, Ho CKL, Leach JK, Marcu L. Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imaging. Tissue Eng Part C Methods. 2011 Apr;17(4):495-504.
Decaris ML, Leach JK. Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation. Ann Biomed Eng. 2011 Apr;39(4):1174-85.
Davis HE, Miller SL, Case EM, Leach JK. Supplementation of fibrin gels with sodium chloride enhances physical properties and ensuing osteogenic response. Acta Biomater. 2011 Feb;7(2):691-9.
Davis HE, Leach JK. Designing bioactive delivery systems for tissue regeneration. Ann Biomed Eng. 2011 Jan;39(1):1-13.
2010
Cheung WK, Working DM, Galuppo LD, Leach JK. Osteogenic comparison of expanded and uncultured adipose stromal cells. Cytotherapy. 2010 Jul; 12(4):554-62.
He J, Genetos DC, Yellowley CE, Leach JK. Oxygen tension differentially influences osteogenic differentiation of human adipose stem cells in 2D and 3D cultures. J Cell Biochem. 2010 May;110(1):87-96.
Rao RR, He J, Leach JK. Biomineralized composite substrates increase gene expression with nonviral delivery. J Biomed Mater Res Part A. 2010 Aug;94(2):344-54.
Genetos DC, Cheung WK, Decaris ML, Leach JK. Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF. J Mol Neurosci. 2010 Mar;40(3):360-6.
He J, Genetos DC, Leach JK. Osteogenesis and trophic factor secretion are influenced by the composition of hydroxyapatite/ poly(lactide-co-glycolide) composite scaffolds. Tissue Eng Part A. 2010 Jan;16(1):127-37.
2009
Decaris ML, Lee CI, Yoder MC, Tarantal AF, Leach JK. Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells. Angiogenesis 2009;12(4):303-11.
Leu A, Steiger SM, Dayton PA, Ferrara KW, Leach JK. Angiogenic response to bioactive glass promotes bone healing in an irradiated calvarial defect. Tissue Eng 2009;15(4): 877-885.
Davis HE, Rao RR, He, J, Leach JK. Biomimetic scaffolds fabricated from apatite-coated microspheres. J Biomed Mater Res Part A; 2009 Sep 15;90(4):1021-31.
2008
Leu A, Leach JK. Proangiogenic potential of a collagen/bioactive glass substrate. Pharm Res 2008;25(5):1222-1229.
Leach JK and Mooney DJ. Synthetic extracellular matrices (editorial). Pharm Res 2008;25(5):1209-1211.
Davis HE and Leach JK. Hybrid and composite biomaterials in tissue engineering. Topics in Multifunctional Biomaterials and Devices e-book, Vol. 1, N. Ashammakhi, Ed, 2008. Link
Leach JK. Keeping an eye on the prize: The need for noninvasive imaging in tissue engineering. Tissue Engineering Research, Nova Science Publishers, Hauppauge, NY, G. Greco, Ed, 2008, pp. 1-6.
Rocha FG, Sundback CA, Krebs NJ, Leach JK, Mooney DJ, Ashley SW, Vacanti JP, Whang EE. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials 2008;29(19):2884-90.
2007
Riddle KW, Kong HJ, Leach JK, Fischbach C, Cheung C, Anseth KS, Mooney DJ. Modifying the proliferative state of target cells to control DNA expression and identifying cell types transfected in vivo. Mol Ther 2007:15(2):361-368.
2006
Leach JK. Multifunctional cell-instructive materials for tissue regeneration. Regen Med 2006;1(4):447-455.
Leach JK, Kaigler D, Wang Z, Krebsbach PH, Mooney DJ. Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials 2006:27:3249-3255.
Sedrakyan S, Zhou ZY, Perin L, Leach K, Mooney D, Kim TH. Tissue engineering of a small hand phalanx with a porously casted polylactic acid-polyglycolic acid copolymer. Tissue Eng 2006;12(9):2675-83.
