HEINRICH LAB


Nano-to-microscale quantitative biophysics and bioengineering. Single-molecule interactions. Biomembrane mechanics. Cell adhesion and cellular shape and motion. Design and advancement of nano-to-micromechanical core technologies: Dynamic force spectroscopy. Dynamic tension spectroscopy. Biomembrane force probe. Optical tweezers. Automated micromanipulation and micropipette aspiration. 

SELECT PUBLICATIONS

Kim, S.V.; Mehal, W.Z.; Dong, X.; Heinrich, V.; Pypaert, M.; Mellman, I.; Dembo, M.; Mooseker, M.S.; Wu, D.; Flavell, R.A. Modulation of cell adhesion and motility in the immune system by Myo1f. Science 2006, 314(5796), 136-139.

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Herant, M.; Heinrich, V.; Dembo, M. Mechanics of neutrophil phagocytosis: experiments and quantitative models. J. Cell Sci. 2006, 119, 1903-1913.

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Heinrich, V.; Leung, A.; Evans, E. Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium. J. Chem. Inf. Model. 2005; 45, 1482-1490. (PERSPECTIVE)

Heinrich, V.; Leung, A.; Evans, E. Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces. II. Tether flow terminated by P-selectin dissociation from PSGL-1. Biophys. J. 2005, 88, 2299-2308.

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Heinrich, V.; Rawicz, W. Automated, high-resolution micropipet aspiration reveals new insight into the physical properties of fluid membranes. Langmuir 2005, 21, 1962-1971.

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Herant, M.; Heinrich, V.; Dembo, M. Mechanics of neutrophil phagocytosis: behavior of the cortical tension. J. Cell Sci. 2005, 118, 1789-1797.

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Evans, E.; Leung, A.; Heinrich, V.; Zhu, C. Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond. Proc. Natl. Acad. Sci. USA 2004, 101, 11281-11286.

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Evans, E.; Heinrich, V.; Ludwig, F.; Rawicz, W. Dynamic tension spectroscopy and strength of biomembranes. Biophys. J. 2003, 85, 2342-2350.

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Heinrich, V.; Bozic, B.; Svetina, S.; Zeks, B. Vesicle deformation by an axial load: from elongated shapes to tethered vesicles. Biophys. J. 1999, 76, 2056-2071.

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Heinrich, V.; Sevsek, F.; Svetina, S.; Zeks, B. Large deviations of the average shapes of vesicles from equilibrium: Effects of thermal fluctuations in the presence of constraints. Phys. Rev. E 1997, 55, 1809-1818.

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Heinrich, V.; Waugh, R. E. A piconewton force transducer and its application to measurement of the bending stiffness of phospholipid membranes. Ann. Biomed. Eng. 1996, 24, 595-605.