Heinrich Lab


→ Undergraduate student Matthew Halverson, who got his first taste of scientific research as a sophomore in our lab, wins the 2012 Ghausi Medal, the highest honor awarded by the College of Engineering to a graduating senior.  Matt also received the 2012 Departmental citation for “Outstanding Academic Achievement”.
→ Our paper on E- and N-cadherin binding (Ounkomol et al. 2010; PDF 369 KB) ranks 16th among the most downloaded papers published in the Biophysical Journal in 2011.  The paper introduced important innovations in AFM-based mechanical testing of cells and molecules.
→ Our movie showing the “chemotactic and phagocytic response of a micropipette-held human neutrophil to zymosan” is in the supplementary material of our paper on the “blurred line between chemotactic chase and phagocytic consumption” (Journal of Cell Science; low-res. PDF 702 KB). The movie met with enthusiasm at the 2011 Gordon Research Conference on Phagocytes and the 55th Annual Meeting of the Coccidioidomycosis Study Group. [Click thumbnail at the far right to play the Quicktime movie in a separate window.]
→ UC Davis Commencement Ceremony (June 9, 2011): Cheng-Yuk Lee and Chek Ounkomol walk…
[Click here for more pictures.]
→ Our paper “Target-specific mechanics of phagocytosis: Protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens” (Lee et al. 2011; PDF 1104 KB) is highlighted in the “In this issue” section at the front of the Journal of Cell Science. [Click thumbnails to play Quicktime movies in separate windows.]
→ Our collaborative, open-access paper “Protrusive push versus enveloping embrace: Computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchors” (Herant et al. 2011) is accessed more than 500 times in the first three weeks after online publication, and reaches 1000 views within ten weeks. [Click thumbnails to play Quicktime movies in separate windows.]
→ Our paper presenting … functionalized microspheres arrayed on AFM cantilevers … (Ounkomol et al. 2010; PDF 369 KB; see also below) is selected and evaluated by a Member of the Faculty of 1000 (F1000), which places this work in the F1000 library of the top 2% of published articles in biology and medicine.
→ Our paper “Single-cell adhesion tests against functionalized microspheres arrayed on AFM cantilevers confirm heterophilic E- and N-cadherin binding” (Ounkomol et al. 2010; PDF 369 KB) is among the top 10 most frequently accessed articles published in the Biophysical Journal in the preceding 30 days. The paper pioneers a new, custom-AFM-based approach to characterize multiple biomolecular interactions of the same cell or functionalized bead in a swift sequential or cyclical manner. [Click thumbnails to play the supplementary Quicktime movies in separate windows.]

Cheng-Yuk Lee wins “Outstanding Poster Award” at 2010 UC Systemwide Bioengineering Symposium.

→ Our work on phagocytosis is featured in the Spring 2010 issue of Biomedical Computation Review (a magazine published by the Simbios National NIH Center for Biomedical Computing).

→ Jonathan Lam is first author on a Biophysical Journal paper on macrophage mechanics (2009; PDF 768 KB). The paper is based on Jon’s work as an undergraduate researcher.

→ Jonathan Lam receives Departmental citation as “Outstanding Undergraduate Researcher” (2008).

→ Our paper on “Biophysics in reverse: Using blood cells to accurately calibrate force-microscopy cantilevers” (Applied Physics Letters 2008; PDF 616 KB) is selected for inclusion in two Virtual Journals: the April 28, 2008 issue of Virtual Journal of Nanoscale Science & Technology, and the May 1, 2008 issue of Virtual Journal of Biological Physics Research. It also is featured in a UC Davis press release, in a spotlight of the popular Nanowerk WEB site, and in the book “Nano-Society – Pushing the Boundaries of Technology“.

Chek Ounkomol‘s performance helps secure a prestigious 2-year GREAT training grant sponsored by the UC Systemwide Biotechnology Research and Education Program (BREP, 2008-2010). See also the UC press release and BME newsletter.

→ Our paper on “Force versus axial deflection of pipette-aspirated closed membranes” (Biophysical Journal 2007; PDF 410 KB) earns a “New and Notable” highlight at the front of the Journal.

→ Our work on phagocytosis mechanics (Herant et al. 2005 and 2006) is discussed in an Opinion by Hallett & Dewitt (2007) in Trends in Cell Biology.
[Click thumbnails to play Quicktime movies in separate windows. See also the Research section.]