The main objective of the laboratory is to understand the healing processes of cartilage, and to augment those processes via sound application of tissue engineering principles. Our approach entails the use of both biomechanical and bioactive agents/signals. By applying forces to the tissue, construct, and single cell levels, we seek to elucidate the anabolic and catabolic thresholds of chondrocyte mechanotransduction and to develop translational technologies that enhance cartilage regeneration. We are also interested in identifying suitable, alternate cell sources, such as embryonic stem cells, dermis-derived aggrecan sensitive stem cells, and mesenchymal stem cells.

As you explore our website, we hope that you gain a better understanding of the key issues and challenges in regenerating cartilage, our main areas of research, the diverse approaches we employ, and most importantly, the people that make up the lab.